The series will be priced at Rs 48.60 lakh. The announcement is part of Mercedes' celebration of 20 years in India.
New Edition E will also be available in three variants - E200, E250 and E350 CDI.
E200 petrol version is priced at 48.6 lakh, the diesel powered E250 and E350 CDI have been priced at Rs 50.7 lakh and Rs 60.61 lakh respectively.
The company said it rolled out its first locally assembled E-Class from India 20 years back.
The company has sold over 32,000 units of E-Class since 1995 in India.