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New blood test can detect tuberculosis 2 years in advance, find scientists

Researchers developed blood test that measures expression levels of four genes that can more accurately predict development of TB

Press Trust of India  |  Johannesburg 

tuberculosis

Scientists have found a new blood test that can accurately predict the development of up to two years, before its onset in high-risk patients.

Those living with someone with active are at highest risk for developing the disease, yet only 5-20 per cent of people infected with develop TB, says a study published in American Journal of Respiratory and Critical Care Medicine. The researchers developed and validated a blood test that measures the expression levels of four genes that can more accurately predict the development of in high-risk patients. “We found that this prediction (up to two years before the onset of the disease) is possible through measurements of a combination of a four-gene signature in the blood,” said from in

Greater accuracy

  • Those living with an active patient are at highest risk for developing it, yet only about 5-20% infected with actually develop TB
  • Researchers have developed a blood test that measures the expression levels of four genes that can accurately predict the development of TB in high-risk patients
This signature, known as ‘RISK4’, is a combination of four genes associated with “The individual components of this signature may not be sufficient to deliver an accurate diagnosis of prediction, but a combination of these markers improves its accuracy,” said Walzl. “We are hoping that primary clinics will be able to use such a test and the reagents would then be readily available in that format, similar to the tests that are currently used to diagnose TB,” he said.

First Published: Sat, April 07 2018. 21:24 IST
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