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Stress caused by financial hardship may up migraine risk: Study

A migraine is a serious and debilitating neurological disease affecting 1 billion people worldwide

Press Trust of India  |  London 

Representational image
Representational image: The CLOCK gene is a gene associated with the sleep-wake cycle 

caused by can increase the risk of developing in people with a particular gene, a study has found.

A is a serious and debilitating neurological disease affecting 1 billion people worldwide.


Researchers, including those from Semmelweis University in Hungary, checked about 2349 patients, for two variants of the CLOCK gene, and how these are associated with a

The is a gene associated with the sleep-wake cycle — also known as the circadian rhythm — that make chronic stress-triggered migraines more common.

It has an important role in regulating many rhythmic patterns of the body, including body temperature or level of cortisol, the primary hormone, researchers said.

They found that there was no significant direct connection between the gene and migraine, but when they factored in (financial stress, measured by a financial questionnaire), they noted that the investigated gene variants increased the odds of having type headaches in those subjects who suffered from by around 20 per cent.

The team looked at functional single nucleotide polymorphisms within the that are able to influence how much protein is transcribed from the gene.

Since this protein controls the body clock machinery these variants may impair processes that can prevent a in the face of

The study does not show what causes a but it does show that both and genetics have an effect. We were able to show that - represented by - led to an increase in a in those who have a particular gene variant," said Daniel Baksa, from Semmelweis University.

First Published: Sun, September 03 2017. 18:58 IST
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