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This 3-in-1 blood test will be a boon for precision prostate cancer therapy

Test would help monitor cancer's evolution over time, whether the drug is working on a patient

IANS  |  London 

DNA, medical, medicine
A researcher, seen through a window, prepares DNA in a laboratory

Opening the door to precision medicine for prostate cancer, researchers have developed a three-in-one that could tell which men would benefit from a class of new drugs, detect early signs of resistance and monitor cancer's evolution over time.

The test could be used to know within a month or two whether the drug is working on a patient. It could help to extend or save lives, by targetting more effectively, while also reducing the side-effects of and ensuring patients do not receive drugs that are unlikely to do them any good.

"Not only could the test have a major impact on the of prostate cancer, but it could also be adapted to open up the possibility of precision medicine to patients with other types of as well," said Johann de Bono, Professor at The Institute of Research, London.

By testing DNA in the bloodstream, researchers found they could pick out which men with advanced prostate were likely to benefit from with a class of new drugs called Poly (ADP-ribose) polymerase (PARP) inhibitors.

They also used the test to analyse DNA in the blood after had started, so people who were not responding could be identified and switched to alternative in as little as four to eight weeks.

And finally, they used the test to monitor a patient's blood throughout treatment, quickly picking up signs that the was evolving genetically and might be becoming resistant to the drugs.

It is the first test developed for a precision prostate targeted at specific genetic faults within tumours, according to the researchers.

It could in future allow the PARP inhibitor olaparib to become a standard for advanced prostate cancer, by targeting the drug at the men most likely to benefit.

The study, published in the journal Discovery, also identified which prostate cancers use to resist with olaparib.

"Our study identifies, for the first time, genetic changes that allow prostate cells to become resistant to the precision medicine olaparib," de Bono said.

"From these findings, we were able to develop a powerful, three-in-one test that could in future be used to help doctors select treatment, check whether it is working and monitor in the longer term. We think it could be used to make clinical decisions about whether a PARP inhibitor is working within as little as four to eight weeks of starting therapy," de Bono added.

First Published: Mon, June 19 2017. 12:53 IST
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