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Alcohol permanently damages DNA in stem cells, increases cancer risk: Study

The study also examined how the body tries to protect itself against damage caused by alcohol

Press Trust of India  |  London 

DNA
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consumption permanently damages the in stem cells, which in turn increases the risk of developing cancer, a study led by an Indian-origin warns.

Much previous research looking at the precise ways in which causes has been done in cell cultures.

However, in the new study, researchers used mice to show how exposure leads to permanent genetic damage.

Scientists at the of at the in the UK gave diluted alcohol, chemically known as ethanol, to mice.

They then used chromosome analysis and sequencing to examine the genetic damage caused by acetaldehyde, a harmful chemical produced when the body processes

The researchers found that acetaldehyde can break and damage within blood leading to rearranged chromosomes and permanently alter the sequences within these cells.

"Some cancers develop due to damage in stem cells," said Professor Ketan Patel from the of

"While some damage occurs by chance, our findings suggest that drinking can increase the risk of this damage," said Patel, lead author of the study published in

It is important to understand how the blueprint within is damaged because when healthy become faulty, they can give rise to cancer, researchers said.

The new findings help us to understand how drinking increases the risk of developing seven types of cancer, including common types like breast and bowel, they said.

The study also examined how the body tries to protect itself against damage caused by The first line of defence is a family of enzymes called aldehyde dehydrogenases (ALDH).

These enzymes break down harmful acetaldehyde into acetate, which our cells can use as a source of

Worldwide, millions of people, particularly those from South East Asia, either lack these enzymes or carry faulty versions of them, researchers said.

When they drink, acetaldehyde builds up which causes a flushed complexion, and also leads to them feeling unwell, they said.

In the study, when mice lacking the critical ALDH enzyme - ALDH2 - were given alcohol, it resulted in four times as much damage in their cells compared to mice with the fully functioning ALDH2 enzyme.

The second line of defence used by cells is a variety of repair systems which, most of the time, allow them to fix and reverse different types of damage.

However, they do not always work and some people carry mutations which mean their cells are not able to carry out these repairs effectively.

"Our study highlights that not being able to process effectively can lead to an even higher risk of alcohol-related damage and therefore certain cancers," Patel said.

"But it is important to remember that clearance and repair systems are not perfect and can still cause in different ways, even in people whose defence mechanisms are intact," he added.

First Published: Thu, January 04 2018. 16:24 IST