To this Hanks, 61, responded saying it was not uncommon that people in high places get away with crimes.
He also condemned the producer's statement justifying his behaviour that he grew up in the '60s and '70s'.
The Oscar-winning actor said, "Look, I don't want to rag on Harvey but so obviously something went down there. You can't buy, 'Oh, well, I grew up in the '60s and '70s and so therefore. ...' I did, too. So I think it's like, well, what do you want from this position of power? I know all kinds of people that just love hitting on, or making the lives of underlings some degree of miserable, because they can.
"Somebody great said this, either Winston Churchill, Immanuel Kant or Oprah: 'When you become rich and powerful, you become more of what you already are'... But I'm not, you know, I'm not the first person to say Harvey's a bit of an a**. Poor Harvey - I'm not going to say poor Harvey, Jesus. Isn't it kind of amazing that it took this long?"
Hanks added he had never worked with Weinstein.
Ryan Gosling too denounced the producer saying that he was "deeply disappointed" in himself for being "oblivious" to Weinstein's horrifying misconduct.
The "Blade Runner 2049" actor issued a statement on Twitter calling out Weinstein.
"I want to add my voice of support for the women who have had the courage to speak out against Harvey Weinstein. Like most people in Hollywood, I have worked with him and I'm deeply disappointed in myself for being so oblivious to these devastating experiences of sexual harassment and abuse.
"He is emblematic of a systemic problem. Men should stand with women and work together until there is real accountability and change."
Gosling had collaborated with Weinstein in the 2010 drama "All Good Things".
Many high profile women such as Cara Delevingne, Lea Seydoux, Heather Graham, Gwyneth Paltrow and Angelina Jolie have alleged Weinstein of sexual harassment after the initial story broke out.
Male stars who joined the growing chorus against Weinstein, includes George Clooney and Mark Ruffalo, while veteran female actors such as Meryl Streep, Glenn Close and Judi Dench called his misconduct inexcusable.
On October 10, The New Yorker published a detailed report highlighting rape allegations against the media mogul by three women, which followed the New York Times expose that outlined years of sexual harassment claims against Weinstein.