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"I want to hear about the silence of (US First Lady) Melania Trump. I want to hear from her. She has so much that's valuable to say. And so does (President Donald Trump's daughter) Ivanka. I want her to speak now," Streep said.
"I really had to think. Because it really underlined my own sense of cluelessness, and also how evil, deeply evil, and duplicitous, a person he was, yet such a champion of really great work," she said.
She added: "You make movies. You think you know everything about everybody. So much gossip. You don't know anything. People are so inscrutable on a certain level. And it's a shock. Some of my favourite people have been brought down by this, and he's not one of them."
The actress, who worked with Weinstein on many films including her Oscar-winning role in "The Iron Lady", faced criticism from some claiming she knew he was a predator, which she denied.
"I really didn't know. I did think he was having girlfriends. But when I heard rumours about actresses, I thought that that was a way of denigrating the actress and her ability to get the job," Streep said.
The actress added: "That really raised my hackles. I didn't know that he was in any way abusing people. He never asked me to a hotel room. I don't know how his life was conducted without people intimately knowing about it."
Streep is one of the 300 women in Hollywood who joined to create Time's Up, a movement for protecting women in all industries.