You are here: Home » News-ANI » Health
Business Standard

Gut bacteria's secretion may help against kidney stone

ANI  |  Washington D.C. [US] 

In a recent research, scientists have discovered that factors secreted by gut bacteria might help prevent or treat kidney stones.

Kidney stones can pose serious health problems for people and can increase their risks of developing chronic kidney disease and kidney failure.

Oxalate is a small anion that can complex with calcium to form calcium oxalate kidney stones under certain conditions and elevated urinary excretion of oxalate can be an indicator of increased risk.

The intestines play a crucial role in oxalate balance and Oxalobacter formigenes (Of) is an anaerobic bacterium that lives in the large intestine and utilizes oxalate as its exclusive energy source.

Expert Hatim Hassan and his team found that factors secreted by Of can stimulate oxalate transport by human intestinal cells grown in tissue culture.

The team also revealed that the mechanisms of the observed stimulation involve the PKA signalling pathway and a protein transporter called SLC26A6.

Importantly, Of factors reduced urinary oxalate excretion by 32.5 percent in mice by stimulating colonic oxalate secretion.

"Probiotic bacteria have several health benefits; however, the difficulties in determining intestinal bacterial bioavailability and biosafety concerns when administering live probiotics are potential problems facing current probiotics clinical applications. Developing probiotics-derived factors as novel therapeutic agents is an alternative approach that addresses such concerns," Hassan explained.

Adding, "The fact that these factors retain their biological activity and can effectively reduce urinary oxalate excretion in mice indicates their significant potential as novel therapeutic agents, and provides a compelling reason for the aggressive pursuit of their characterization, which is currently underway."

The findings appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

RECOMMENDED FOR YOU

Gut bacteria's secretion may help against kidney stone

In a recent research, scientists have discovered that factors secreted by gut bacteria might help prevent or treat kidney stones.Kidney stones can pose serious health problems for people and can increase their risks of developing chronic kidney disease and kidney failure.Oxalate is a small anion that can complex with calcium to form calcium oxalate kidney stones under certain conditions and elevated urinary excretion of oxalate can be an indicator of increased risk.The intestines play a crucial role in oxalate balance and Oxalobacter formigenes (Of) is an anaerobic bacterium that lives in the large intestine and utilizes oxalate as its exclusive energy source.Expert Hatim Hassan and his team found that factors secreted by Of can stimulate oxalate transport by human intestinal cells grown in tissue culture.The team also revealed that the mechanisms of the observed stimulation involve the PKA signalling pathway and a protein transporter called SLC26A6.Importantly, Of factors reduced ...

In a recent research, scientists have discovered that factors secreted by gut bacteria might help prevent or treat kidney stones.

Kidney stones can pose serious health problems for people and can increase their risks of developing chronic kidney disease and kidney failure.

Oxalate is a small anion that can complex with calcium to form calcium oxalate kidney stones under certain conditions and elevated urinary excretion of oxalate can be an indicator of increased risk.

The intestines play a crucial role in oxalate balance and Oxalobacter formigenes (Of) is an anaerobic bacterium that lives in the large intestine and utilizes oxalate as its exclusive energy source.

Expert Hatim Hassan and his team found that factors secreted by Of can stimulate oxalate transport by human intestinal cells grown in tissue culture.

The team also revealed that the mechanisms of the observed stimulation involve the PKA signalling pathway and a protein transporter called SLC26A6.

Importantly, Of factors reduced urinary oxalate excretion by 32.5 percent in mice by stimulating colonic oxalate secretion.

"Probiotic bacteria have several health benefits; however, the difficulties in determining intestinal bacterial bioavailability and biosafety concerns when administering live probiotics are potential problems facing current probiotics clinical applications. Developing probiotics-derived factors as novel therapeutic agents is an alternative approach that addresses such concerns," Hassan explained.

Adding, "The fact that these factors retain their biological activity and can effectively reduce urinary oxalate excretion in mice indicates their significant potential as novel therapeutic agents, and provides a compelling reason for the aggressive pursuit of their characterization, which is currently underway."

The findings appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

image
Business Standard
177 22

Gut bacteria's secretion may help against kidney stone

In a recent research, scientists have discovered that factors secreted by gut bacteria might help prevent or treat kidney stones.

Kidney stones can pose serious health problems for people and can increase their risks of developing chronic kidney disease and kidney failure.

Oxalate is a small anion that can complex with calcium to form calcium oxalate kidney stones under certain conditions and elevated urinary excretion of oxalate can be an indicator of increased risk.

The intestines play a crucial role in oxalate balance and Oxalobacter formigenes (Of) is an anaerobic bacterium that lives in the large intestine and utilizes oxalate as its exclusive energy source.

Expert Hatim Hassan and his team found that factors secreted by Of can stimulate oxalate transport by human intestinal cells grown in tissue culture.

The team also revealed that the mechanisms of the observed stimulation involve the PKA signalling pathway and a protein transporter called SLC26A6.

Importantly, Of factors reduced urinary oxalate excretion by 32.5 percent in mice by stimulating colonic oxalate secretion.

"Probiotic bacteria have several health benefits; however, the difficulties in determining intestinal bacterial bioavailability and biosafety concerns when administering live probiotics are potential problems facing current probiotics clinical applications. Developing probiotics-derived factors as novel therapeutic agents is an alternative approach that addresses such concerns," Hassan explained.

Adding, "The fact that these factors retain their biological activity and can effectively reduce urinary oxalate excretion in mice indicates their significant potential as novel therapeutic agents, and provides a compelling reason for the aggressive pursuit of their characterization, which is currently underway."

The findings appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

image
Business Standard
177 22

Upgrade To Premium Services

Welcome User

Business Standard is happy to inform you of the launch of "Business Standard Premium Services"

As a premium subscriber you get an across device unfettered access to a range of services which include:

  • Access Exclusive content - articles, features & opinion pieces
  • Weekly Industry/Genre specific newsletters - Choose multiple industries/genres
  • Access to 17 plus years of content archives
  • Set Stock price alerts for your portfolio and watch list and get them delivered to your e-mail box
  • End of day news alerts on 5 companies (via email)
  • NEW: Get seamless access to WSJ.com at a great price. No additional sign-up required.
 

Premium Services

In Partnership with

 

Dear Guest,

 

Welcome to the premium services of Business Standard brought to you courtesy FIS.
Kindly visit the Manage my subscription page to discover the benefits of this programme.

Enjoy Reading!
Team Business Standard