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How fast food is damaging your immune system

ANI  |  Washington D.C. [USA] 

makes the more aggressive in the long term, suggest researchers.

According to the study, even after a change to a healthy diet, the body's defenses remain hyperactive.

These long-term changes may be involved in the development of and diabetes, linked to Western diet consumption.

The scientists placed mice for a month on a so-called "Western diet": high in fat, high in sugar, and low in fiber. The animals consequently developed a throughout the body, almost like after with dangerous bacteria.

"The unhealthy diet led to an unexpected increase in the number of certain immune cells in the blood of the mice, especially granulocytes and monocytes. This was an indication for an involvement of immune cell progenitors in the bone marrow," Anette Christ, postdoctoral fellow in the of the explains.

To better understand these unexpected findings, bone marrow progenitors for major immune cell types were isolated from mice fed a Western diet or healthy control diet and a systematic analysis of their function and activation state was performed.

"Genomic studies did, in fact, show that the Western diet had activated a large number of genes in the progenitor cells. The genes affected included those responsible for proliferation and maturation", explains Prof. Dr.

thus causes the body to quickly recruit a huge and powerful army. When the researchers offered the rodents their typical cereal diet for another four weeks, the disappeared. What did not disappear was the genetic reprogramming of the immune cells and their precursors: Even after these four weeks, many of the genes that had been switched on during the phase were still active.

"It has only recently been discovered that the innate has a form of memory", explains Prof. Dr.

"After an infection, the body's defenses remain in a kind of alarm state, so that they can respond more quickly to a new attack." Experts call this "innate immune training". In the mice, this process was not triggered by a bacterium, but by an unhealthy diet.

The scientists were further able to identify the responsible "sensor" in immune cells. They examined blood cells from 120 subjects. In some of the subjects, the innate showed a particularly strong training effect. In these subjects, the researchers found genetic evidence of the involvement of a so-called inflammasome.

Inflammasomes are key intracellular signaling complexes that recognize and other harmful substances and subsequently release How exactly the NLRP3 inflammasome recognizes the exposure of the body to Western type diets remains to be determined.

Interestingly, in addition to the acute inflammatory response, this also has long-term consequences for the immune system's responses: The activation by Western diet changes the way in which the genetic information is packaged. The genetic material is stored in the DNA and each cell contains several DNA strands, which together are about two meters long.

However, they are typically wrapped around certain proteins in the nucleus and thus many genes in the DNA cannot be read as they are simply too inaccessible.

Unhealthy eating causes some of these normally hidden pieces of DNA to unwind, similar to a loop hanging out of a ball of wool. This area of the genetic material can then be read much easier as long as this temporary unwrapping remains active. Scientists call these phenomena epigenetic changes. "The inflammasome triggers such epigenetic changes", explains Dr. Latz. "The consequently reacts even to small stimuli with "

These in turn accelerate the development of or type 2

In for example, the typical vascular deposits, the plaques, consist largely of lipids and immune cells. The contributes directly to their growth, because newly activated immune cells constantly migrate into the altered vessel walls.

When the plaques grow too large, they can burst, leading to blood clotting and are carried away by the bloodstream and can clog vessels. Possible consequences: or

Wrong nutrition can thus have dramatic consequences.

"These findings therefore have important societal relevance", explains Latz. "The foundations of a healthy diet need to become a much more prominent part of education than they are at present. Only in this way can we immunize children at an early stage against the temptations of the industry. Children have a choice of what they eat every day. We should enable them to make conscious decisions regarding their dietary habits."

The results are published in the journal Cell.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Fri, January 12 2018. 12:10 IST