The 30-year-old had earlier accepted a wildcard entry to make her first appearance at the tournament since 2006.
Tournament director Salah Tahlak confirmed the news, saying, "Unfortunately both Maria Sharapova and Madison Keys have regretfully had to withdraw from the Dubai Duty-Free Tennis Championships due to injury and illness.
"We are sorry that neither Maria nor Madison will be able to play in Dubai, but we still have one of the strongest fields ever assembled for the WTA event," the Daily Express quoted Tahlak, as saying.
Five-time Grand Slam champion and the Russian tennis star Sharapova has a 21-10 win-loss record since making a return to the tennis court from a 15-month doping suspension last April.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)