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22 new genetic risk factors for stroke identified

IANS  |  New York 

Scientists, including one of Indian-origin, have identified 22 new genetic risk factors for stroke, from samples of 520,000 individuals worldwide, thus tripling the number of gene regions known to affect risk.

is the second most common cause of both death and disability-adjusted life-years worldwide, but its molecular mechanisms remain poorly understood.

Previously, only 10 genetic risk factors had been identified for

"Understanding these newly identified risk factors for should also enable us to find novel treatments for dementia," said Sudha Seshadri, University of Texas-San Antonio, US.

"in the brain -- a series of -- can lead to dementia," Seshadri added.

The results, published in the journal Nature Genetics, demonstrated shared genetic influences with multiple related vascular conditions, especially blood pressure, but also coronary artery disease, and others.

Linking these results with extensive biological databases provides novel clues on mechanisms and illustrates the potential of to identify drug targets for therapy, the researchers said.

can originate from alterations in various parts of the vasculature including large arteries, small arteries, the heart, and the venous system and the researchers found genetic risk factors implicated in each of these mechanisms.

The study showed that some genetic risk factors contribute to specific mechanisms and others to susceptibility at large.

Further, the researchers noticed that several of them overlap with genomic areas known to be implicated in related vascular conditions such as atrial fibrillation, coronary artery disease, venous thrombosis, or vascular risk factors, especially elevated blood pressure, and less so

In addition, the researchers found that the genes they identified are enriched in drug targets for antithrombotic therapy, used to re-open occluded blood vessels in patients with acute or to prevent vascular events including

"These genetic findings represent a first step towards developing personalised, evidence-based treatments for this They provide evidence for several novel biological pathways involved in that may lead to the discovery of novel drug targets," explained Rainer Malik, from the Ludwig-Maximilians-Universitaet (LMU) in Munich,



(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Tue, March 13 2018. 18:42 IST