Among the deceased was a 14-year-old boy and reports from the Palestinian Health Ministry and the Red Crescent medical relief group said hundreds were suffering from gunshot wounds, while many others were hit by shrapnel or affected by smoke, the BBC reported.
Witnesses said that several Palestinians managed to get through the security fence and that tens or hundreds were crossing into the Israeli territory.
The demonstrations and general strikes had been planned to protest against the US embassy's relocation from Tel Aviv to Jerusalem, which many consider contravenes international consensus to not recognize the city as Israel's capital until its status is established during negotiations.
Palestinians see East Jerusalem, which was occupied by Israel during the 1967 Six Day War and later annexed in 1980, as the capital of their future state.
The timing of the move has also been slammed, as it is being held a day ahead of Nakba Day ("Day of the Catastrophe"), which this year marks the 70th anniversary of Israel's creation and subsequent displacement of some 700,000 Palestinian refugees.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)