Runaway leaders Bayern Munich showed no mercy with Hamburg as three goals from Lewandowski on Saturday, two from Franck Ribery and one from Arjen Robben increase Hamburg's relegation worries, reports Xinhua news agency.
Bayern gained momentum and pressed Hamburg into defence before Lewandowski headed home Joshua Kimmich's cross to double the lead in the 12th minute.
The pole remained in the thick of things as he tripled the lead moments later when he tapped home an assist from David Alaba with 19 minutes played.
Hamburg were unable to put up resistance whereas Bayern started where they left off before the half time as Dutchman Arjen Robben made it 4-0 on the scoreboards 10 minutes into the second half.
The hosts remained on the front foot as Ribery shrugged off three defenders before slamming home the fifth goal from inside the box with nine minutes to the final whistle.
Bayern's Lewandowski should have extended the lead but the striker squandered a penalty as he pulled over the target.
However, the Pole made amends as he converted another penalty to seal his hat-trick in the closing period.
With the result, Bayern established their 20-point advantaged atop the standings, while Hamburg were stuck at the 17th place with seven points to safety.
Hoffenheim's dominant performance got rewarded on 18 minutes as Casteels blocked Florian Grillitsch's cross into the path of Schulz, who made no mistake to break the deadlock.
Wolfsburg lacked penetration and were unable to threat Hoffenheim's defence whereas the hosts failed to make the most out of their chances as Serge Gnabry rattled the woodwork and saw his header scratched off the line before the break.
Things went from bad to worse three minutes later as Wolfsburg's Guilavogui scored an own goal to put the result beyond doubt with 10 minutes from time.
After suffering their ninth loss of the season, Wolfsburg remain in touching distance to the drop zone while the seventh-placed Hoffenheim have increased their chances for a berth in Europe.