The two sides battled to a scoreless draw two weeks ago in the first leg in Seville and it was clear from the start of Tuesday's contest that United coach Jose Mourinho would stick with the same approach: Concede possession and wait for chances on the counter, Efe news reported.
But the visitors went for broke, determined to get into the next phase after going out of the tournament in the round of 16 on their last three occasions.
Mourinho's tactics looked like paying off in the first minute in front of a 74,000 crowd at Old Trafford, as Romelu Lukaku powered past Sevilla defender Kjaer and menaced the opposing goal.
Sevilla keeper Sergio Rico had to make a save after Marcus Rashford's free kick took a threatening turn after deflecting off the defensive wall.
Rico had to be sharp again at the start of the second half to bat away a shot from Jesse Lingard as United began showing more ambition.
Ben Yedder etched his name in the history of "the theatre of dreams" the first time he touched the ball, taking a pass from Sarabia and eluding Bailly to put the ball just inside David De Gea's post to make it 1-0 for Sevilla.
But before the changes could make a difference, Ben Yedder struck again in the 78th minute to make United's task even harder.
Lukaku clawed one back for United with six minutes left to avoid the home shutout.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)