The Spanish-language hit disappeared from Google-owned platform on Tuesday, with a pro-Palestine message from the hackers. The video was later restored.
"A hacker using the online moniker 'Kuroi'SH' claimed responsibility for the breach in a series of tweets, revealing that he also hacked rapper Post Malone and YouTube CEO Susan Wojcicki," news.sky.com reported.
The hackers changed the video's title to "hacked by Kuroi'Sh & Prosox".
"Despacito" was among several other videos reportedly defaced with pro-Palestine messages by hackers.
The hacker Kuroi'SH is believed to have hacked Google Brazil last year.
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