In a statement, the ministry accused the US warplanes of "committing a massacre" against pro-government forces that were confronting the Islamic State (IS).
Calling it a "new barbaric aggression", the ministry said the US attack came in the framework of the Washington's "aggressive policies" against Syria, Xinhua reported.
The pro-government Syrian forces were confronting IS, "who are under the protection" of the US coalition and the allied forces of the Syrian Democratic Forces (SDF), it added.
The Syrian government urged the UN Security Council to condemn the massacre and to hold the US coalition responsible for their "crimes and aggression that have left thousands of civilians either killed or wounded," the statement said.
Meanwhile, SANA reported that U.S. warplanes carried out 10 airstrikes on the positions of the pro-government forces after midnight on Saturday.
According to the London-based Syrian Observatory for Human Rights, at least 45 pro-government fighters were killed in the airstrikes.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)