You are here: Home » News-IANS » Health-Medicine
Business Standard

Why HIV infection ups TB risk

IANS  |  London 

Researchers have found that the HIV virus increases the potency of the bacterium (Mtb) by affecting a central function of the immune system.

In most people who are exposed to infection, the immune defence deals with the bacteria by enclosing them in a special scar tissue. In this condition the is said to be "latent". Around 10 per cent of those with latent go on to develop active disease.

"The risk of infection progressing to active is around 30 times higher for people who are HIV-positive. But the reason for this has not been known at the cellular level," said lead researcher Robert Blomgran from Linkoping University in Sweden.

The new study, published in the American Journal of Pathology, describes how the researchers looked in more detail at what happens in one particular type of immune cell, known as dendritic cells.

These play an important role in the immune defence. Dendritic cells break down bacteria and other foreign microorganisms, and display the bacteria fragments at the cell surface.

Other cells of the immune system, in particular T-cells, recognise the fragments and bind to them.

The dendritic cell then activates the T-cell such that it can kill the bacteria efficiently.

In this way, dendritic cells act as a communication link between the innate immune defence and the specific immune defence, of which the T-cells are part.

The researchers infected human dendritic cells with both Mtb and the HIV virus. They showed that co-infection reduced the ability of the dendritic cells to present foreign molecules to the immune defence.

They also had a lower capacity to activate tuberculosis-specific T-cells than was the case when the dendritic cells were infected with Mtb alone.

"We have now shown that HIV has a clear effect also on the innate immune defence, in particular the dendritic cells, which link the innate and the adaptive immune defences," Blomgran said.

--IANS

gb/vm

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

RECOMMENDED FOR YOU

Why HIV infection ups TB risk

Researchers have found that the HIV virus increases the potency of the tuberculosis bacterium (Mtb) by affecting a central function of the immune system.

Researchers have found that the HIV virus increases the potency of the bacterium (Mtb) by affecting a central function of the immune system.

In most people who are exposed to infection, the immune defence deals with the bacteria by enclosing them in a special scar tissue. In this condition the is said to be "latent". Around 10 per cent of those with latent go on to develop active disease.

"The risk of infection progressing to active is around 30 times higher for people who are HIV-positive. But the reason for this has not been known at the cellular level," said lead researcher Robert Blomgran from Linkoping University in Sweden.

The new study, published in the American Journal of Pathology, describes how the researchers looked in more detail at what happens in one particular type of immune cell, known as dendritic cells.

These play an important role in the immune defence. Dendritic cells break down bacteria and other foreign microorganisms, and display the bacteria fragments at the cell surface.

Other cells of the immune system, in particular T-cells, recognise the fragments and bind to them.

The dendritic cell then activates the T-cell such that it can kill the bacteria efficiently.

In this way, dendritic cells act as a communication link between the innate immune defence and the specific immune defence, of which the T-cells are part.

The researchers infected human dendritic cells with both Mtb and the HIV virus. They showed that co-infection reduced the ability of the dendritic cells to present foreign molecules to the immune defence.

They also had a lower capacity to activate tuberculosis-specific T-cells than was the case when the dendritic cells were infected with Mtb alone.

"We have now shown that HIV has a clear effect also on the innate immune defence, in particular the dendritic cells, which link the innate and the adaptive immune defences," Blomgran said.

--IANS

gb/vm

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

image
Business Standard
177 22

Why HIV infection ups TB risk

Researchers have found that the HIV virus increases the potency of the bacterium (Mtb) by affecting a central function of the immune system.

In most people who are exposed to infection, the immune defence deals with the bacteria by enclosing them in a special scar tissue. In this condition the is said to be "latent". Around 10 per cent of those with latent go on to develop active disease.

"The risk of infection progressing to active is around 30 times higher for people who are HIV-positive. But the reason for this has not been known at the cellular level," said lead researcher Robert Blomgran from Linkoping University in Sweden.

The new study, published in the American Journal of Pathology, describes how the researchers looked in more detail at what happens in one particular type of immune cell, known as dendritic cells.

These play an important role in the immune defence. Dendritic cells break down bacteria and other foreign microorganisms, and display the bacteria fragments at the cell surface.

Other cells of the immune system, in particular T-cells, recognise the fragments and bind to them.

The dendritic cell then activates the T-cell such that it can kill the bacteria efficiently.

In this way, dendritic cells act as a communication link between the innate immune defence and the specific immune defence, of which the T-cells are part.

The researchers infected human dendritic cells with both Mtb and the HIV virus. They showed that co-infection reduced the ability of the dendritic cells to present foreign molecules to the immune defence.

They also had a lower capacity to activate tuberculosis-specific T-cells than was the case when the dendritic cells were infected with Mtb alone.

"We have now shown that HIV has a clear effect also on the innate immune defence, in particular the dendritic cells, which link the innate and the adaptive immune defences," Blomgran said.

--IANS

gb/vm

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

image
Business Standard
177 22

Upgrade To Premium Services

Welcome User

Business Standard is happy to inform you of the launch of "Business Standard Premium Services"

As a premium subscriber you get an across device unfettered access to a range of services which include:

  • Access Exclusive content - articles, features & opinion pieces
  • Weekly Industry/Genre specific newsletters - Choose multiple industries/genres
  • Access to 17 plus years of content archives
  • Set Stock price alerts for your portfolio and watch list and get them delivered to your e-mail box
  • End of day news alerts on 5 companies (via email)
  • NEW: Get seamless access to WSJ.com at a great price. No additional sign-up required.
 

Premium Services

In Partnership with

 

Dear Guest,

 

Welcome to the premium services of Business Standard brought to you courtesy FIS.
Kindly visit the Manage my subscription page to discover the benefits of this programme.

Enjoy Reading!
Team Business Standard