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Why living in high altitudes raises depression, suicide risks

IANS  |  New York 

People living in the high-altitude areas have increased rates of and depression, possibly due to reduced levels in their blood, finds a study.

Chronic hypobaric -- a condition whereby blood levels gets reduced due to low atmospheric pressure -- may affect the mood and suicidal thoughts of a person living at altitudes between about 2,000 and 3,000 feet above the sea level.

and (MDD) are complex conditions that almost certainly arise from the influences of many interrelated factors.

"There are significant regional variations in the rates of and suicide, suggesting that sociodemographic and environmental conditions play a role," said Brent Michael Kious, post-doctoral student at the in the US.

Hypobaric could promote and by altering serotonin metabolism and brain bioenergetics -- both of these pathways are implicated in depression, and both are affected by hypoxia, the study showed.

The study, published in the journal Review of Psychiatry, noted that the other factors linked to rate include increased poverty rate, lower income, and divorced women.

Researchers analysed 12 studies, mostly performed in the US, including population-based data on the relationship between or and altitude.

The results found that populations living at higher altitudes had increased rates despite having decreased rates of death from all causes, including substance abuse and cultural differences.

Some possible treatments to mitigate the effects of altitude on and risk include supplemental 5-hydroxytryptophan (a serotonin precursor) to increase serotonin levels, or creatinine to influence brain bioenergetics, the researchers said.



(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Sat, March 10 2018. 18:40 IST