The 37-year-old rapper, whose real name is Curtis Jackson, has always been a musical rival of West's but now he may have ignited a bigger feud by commenting on his choice of girlfriend, reported Sun online.
"I mean... If that man feel like she's perfect, then she's perfect. He could mean it and you'll end up singing the words to it because he's Kanye... You know how it is? One man's trash is another man's treasure," he said.
50 Cent, who used to date talk show host Chelsea Handler, said he did not know if there was such a thing as a perfect woman.
"I'm not sure. The smartest guys I know have lost being a bad judge of character in that area."