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76 genes that make bacteria drug-resistant identified

Press Trust of India  |  London 

Scientists have identified 76 previously unknown that make resistant to last-resort antibiotics, a finding that could bolster mankind's fight against superbugs.

The increasing number of infections caused by antibiotic-resistant is a rapidly growing global problem.

Disease-causing become resistant through mutations of their own or by acquiring resistance from other, often harmless,

By analysing large volumes of data, the researchers at Chalmers University of Technology and the University of Gothenburg in Sweden, found 76 new types of resistance

Several of these can provide with the ability to degrade carbapenems, the most powerful class of antibiotics used to treat multi-resistant

"Our study shows that there are lots of unknown resistance Knowledge about these makes it possible to more effectively find and hopefully tackle new forms of multi-resistant bacteria," said Erik Kristiansson, professor at Chalmers University of Technology.

"The more we know about how can defend themselves against antibiotics, the better are our odds for developing effective, new drugs," said Joakim Larsson, professor at the University of Gothenburg.

The study, published in the scientific journal Microbiome, identified the novel by analysing sequences from collected from humans and various environments from all over the world.

"Resistance are often very rare, and a lot of data needs to be examined before a new gene can be found," Kristiansson said.

Identifying a resistance gene is also challenging if it has not previously been encountered. The research group solved this by developing new computational methods to find patterns in that are associated with antibiotic resistance.

By testing the they identified in the laboratory, they could then prove that their predictions were correct.

"Our methods are very efficient and can search for the specific patterns of novel resistance in large volumes of sequence data," said Fanny Berglund, a PhD student in the research group.

The next step for the research groups is to search for that provide resistance to other forms of antibiotics.

"The novel we discovered are only the tip of the iceberg. There are still many unidentified antibiotic resistance that could become major global health problems in the future," Kristiansson said.

(Only the headline and picture of this report may have been reworked by the Business Standard staff; the rest of the content is auto-generated from a syndicated feed.)

First Published: Mon, October 16 2017. 12:07 IST