De Villiers, who quit as Proteas Test captain last year, will lead the T20 side in the absence of regular captain Faf du Plessis, who has a niggling shoulder injury and has returned home to be with his wife Imari for the birth of their first baby.
CSA National Selection Panel convener, Linda Zondi thanked acting captain Farhaan Behardien for leading the side to victory against visitors Sri Lanka before the English tour.
"We are indeed fortunate in the quality of our team leaders and Farhaan remains very much part of this group," Zondi said.
"We have also been impressed as a panel by the quality of players coming through our franchise and South Africa 'A' system and we are ready to give further opportunities to Andile Phehlukwayo, Mangaliso Mosehle, Jon-Jon Smuts and Dane Paterson who all made their debuts in the recent series against Sri Lanka. Unfortunately, Lungi Ngidi could not be considered because of injury," Zondi added.
"This is an exciting opportunity for the newcomers to play alongside world-class and experienced players like AB, Farhaan, David Miller, Imran Tahir, Morne Morkel, Chris Morris and Wayne Parnell."
There is one new cap in this format in Dwaine Pretorius, who has been a regular member of the ODI squad during the past season.
The three games will be played on June 21 in Southampton; June 23 in Taunton and June 25 in Cardiff.
South Africa T20 Squad: AB de Villiers (captain), Farhaan Behardien; Reeza Hendricks; Imran Tahir; David Miller; Morne Morkel; Chris Morris; Mangaliso Mosehle; Wayne Parnell; Dane Paterson; Andile Phehlukwayo; Dwaine Pretorius; Tabraiz Shamsi; and Jon-Jon Smuts.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)