Taking part in aerobic exercises for four times a week may increase brain volume in people with mild cognitive impairment (MCI), a condition linked with higher risk of developing Alzheimer's disease, a new study has found.
The study included 35 adults with MCI participating in a randomised, controlled trial of exercise intervention.
"Even over a short period of time, we saw aerobic exercise lead to a remarkable change in the brain," said lead investigator Laura D Baker from Wake Forest School of Medicine (WFSM) in the US.
The participants were divided into two groups. Sixteen adults (average age 63 years) engaged in aerobic activity, including treadmill, stationary bike or elliptical training, four times per week for six months.
A control group of 19 adults (average age 67 years) participated in stretching exercises with the same frequency.
High-resolution brain MR images were acquired from all participants before and after the six-month activity period.
The MRI results were compared using conventional and biomechanical metrics to measure the change in both brain volume and shape.
"We used high-resolution MR images to measure anatomical changes within areas of the brain to obtain both volumetric data and directional information," said Jeongchul Kim from WFSM.
The analysis revealed that for both the aerobic and stretching groups, brain volume increased in most gray matter regions, including the temporal lobe, which supports short-term memory.
"Compared to the stretching group, the aerobic activity group had greater preservation of total brain volume, increased local gray matter volume and increased directional stretch of brain tissue," said Kim.
Among participants of the stretching group, the analysis revealed a local contraction, or atrophy, within the white matter connecting fibers.
According to Kim, such directional deformation, or shape change, is partially related to volume loss, but not always.
"Directional changes in the brain without local volume changes could be a novel biomarker for neurological disease," he said.
"It may be a more sensitive marker for the tiny changes that occur in a specific brain region before volumetric changes are detectable on MRI," he added.
He said both MRI measures are important to the treatment of MCI and AD, which require the careful tracking of changes in the brain while patients engage in interventions including diet and exercise to slow the progression of the disease.
Study participants were tested to determine the effect of exercise intervention on cognitive performance.
Participants in the aerobic exercise group showed statistically significant improvement in executive function after six months, whereas the stretching group did not improve.
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