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'Cancer bubbles' during chemotherapy may cause deadly clotting

Press Trust of India  |  Melbourne 

Chemotherapy may stimulate the release of tiny bubbles from the surface of cells that can cause potentially fatal blood clots, a new study has found.

Most deaths from are caused by uncontrolled growth of the tumour in vital organs. However, the second most common way that kills is by triggering blood clotting resulting in thrombosis, such as pulmonary embolisms.


This causes blockage of major blood vessels - preventing oxygen and nutrients from reaching vital organs.

Though often life-saving and life-prolonging, chemotherapy is associated with a six to seven-fold increase in the risk of thrombosis in patients.

The link between and thrombosis was noted over 100 years ago, but the reasons for the association have been elusive.

Researchers from University of Otago in discovered that cells treated with chemotherapy release lipid-rich bubbles from their membranes that activate coagulation (clotting) processes.

"We now have insight into how these bubbles from dying cells may cause thrombosis during chemotherapy," said Alex McLellan, associate professor at University of Otago.

Researchers have demonstrated that certain solid cancers are more active in promoting blood coagulation, as compared to lymphomas.

"A general pattern is that cancers such as pancreatic, lung and brain cancers carry the largest risk of thrombotic events," said McLellan.

The group analysed the contribution of individual coagulation factors to the risk.

Although they identified the coagulation factor known as Factor V on the bubbles, it was not essential for the rapid clotting induced by the bubbles.

Instead an over-abundance of clotting lipids and a molecule called Tissue Factor on the bubbles were responsible.

"While chemotherapy can be lifesaving, it does carry some risks. A new challenge is being able to identify those patients most at risk and providing effective management to mitigate this risk," said McLellan.

The study was published in the journals Biochimica et Biophysica Acta and Oncotarget.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

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