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Fast paper-based tuberculosis test developed

Press Trust of India  |  Beijing 

Scientists have developed a fast, paper-based test to diagnose that can be read with a smartphone, a technology that is increasingly available in emerging economies.

Diagnosing (TB) early can allow patients to receive the medicine they need and also help prevent the disease from spreading.


However, in resource-limited areas, equipment requirements and long wait times for are obstacles to diagnosis and treatment.

To tackle this problem, Chien-Fu Chen from National University and colleagues come up with a more practical diagnostic test that can be read with a smartphone.

The researchers combined gold nanoparticles with fluorescent single-stranded sequences that bind to the genetic material of Mycobacterium tuberculosis, the bacteria that cause TB.

These nanoparticles were then incorporated into a paper- based device. Adding even a minute amount of lab-derived, double-stranded from M changed the colour of the test spots within an hour.

A smartphone camera was used to analyse the colour change to determine the bacterial concentration.

The researchers also tested a tissue sample from an infected patient to further demonstrate that the device could be used in the field.

The World Health Organization (WHO) estimates that in 2015, 1.4 million people died from TB, with most of these deaths occurring in low- and middle-income countries, researchers said.

Early diagnosis could help curb these numbers. However, conventional methods such as sputum smear microscopy, chest X-rays and molecular-based tests require equipment, electricity and specialised personnel that are not always available in remote or developing areas.

The research was published in the journal ACS Sensors.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Thu, September 14 2017. 12:32 IST
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