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'Heart-muscle patches improve recovery from heart attacks'

Press Trust of India  |  New York 

Heart-patches created from human cells may significantly improve recovery from a attack, a study has found.

The are a step closer to the goal of treating human attacks by suturing cardiac-patches over an area of dead in order to reduce the pathology that often leads to failure.

Each patch is 1.57 by 0.79 inches in size and nearly as thick as a dime.

Researchers from the University of at Birmingham in the US found that transplanting two of these patches onto the infarcted area of a pig significantly improved function of the heart's left ventricle, the major pumping chamber.

The patches also significantly reduced infarct size, which is the area of dead muscle; heart-wall stress and heart-enlargement; as well as significantly reducing apoptosis, or programmed cell death, in the boarder area around the dead

Furthermore, the patches did not induce in the hearts, a serious complication observed in some past biomedical engineering approaches to treat attacks.

Each patch is a mixture of three cell types 4 million cardiomyocytes, or heart-cells; 2 million endothelial cells, which are well-known to help cardiomyocytes survive and function in a micro-environment; and 2 million smooth cells, which line blood vessels.

The three cell types were differentiated from cardiac- lineage, human induced pluripotent stem cells, or hiPSCs, rather than using hiPSCs created from skin cells or other cell types.

Each patch was grown in a three-dimensional fibrin matrix that was rocked back and forth for a week. The cells begin to beat synchronously after one day.

This mixture of three cell types and the dynamic rocking produced more cells that were more mature, with superior heart-physiological function and contractive force.

The patches resembled native heart-tissue in their physiological and contractile properties.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Sat, January 13 2018. 15:20 IST