"The killing of children, women and defenceless people of Palestine and the occupation of Palestinian lands has become the main strategy of the Zionists over the 70 years of occupation," said foreign ministry spokesman Bahram Ghasemi on the ministry's website.
He called on the international community to take "immediate action" and try Israeli leaders as "war criminals in international courts".
"History will judge that both of these decisions by the American government have been very wrong," he told reporters, according to state broadcaster IRIB.
"The main result of this wrong decision is Washington's isolation in global public opinion," he added.
"All these cases show that America intends to destroy the international institution of the United Nations," he told parliament on Tuesday.
"It is driving the international scene to a kind of security chaos," he added. The US blocked a UN resolution on Monday calling for an international investigation into the Gaza killings.
"Israeli regime massacres countless Palestinians in cold blood as they protest in the world's largest open air prison," he wrote on Twitter.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)