You are here: Home » PTI Stories » National » News
Business Standard

Ketamine nasal spray can fight depression, suicidal thoughts

Press Trust of India  |  Washington 

A novel nasal spray of - often misused as a party drug - can rapidly treat symptoms of major depression, and suicidal thoughts, a study has found.

The study, published in The American Journal of Psychiatry, compared an intranasal formulation of esketamine, part of the molecule, to a placebo for rapid treatment of symptoms of major depression, including suicidality, among individuals at imminent suicide risk.

The researchers at the in the US involved 68 participants randomly assigned to one of two groups - either receiving esketamine or placebo twice a week for four weeks alongside standard treatment with antidepressants.

They looked at effects at four hours after first treatment, at 24 hours and at 25 days.

Researchers, including those from and Development, found a significant improvement in depression scores and decreased in the esketamine group compared to the placebo group at four hours and at 24 hours.

The esketamine effects were not greater than the placebo at 25 days. The measurement of suicide risk took into consideration both the patient's and clinician's perspectives.

The results of the study support nasal spray esketamine as a possible effective rapid in patients assessed to be at imminent risk for suicide, researchers said.

Esketamine could be an important treatment to bridge the gap that exists because of the delayed effect of most common antidepressants. Most antidepressants take four to six weeks to become fully effective.

The scientists caution that more research is needed on the potential for abuse of

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

First Published: Mon, April 16 2018. 11:00 IST
RECOMMENDED FOR YOU