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The 500-kilogramme German bomb was found early on Sunday morning in King George V Dock, during planned works close to London's most central airport.
As bomb disposal experts from the police and Royal Navy worked to move the unexploded ordnance, the airport was shut down and two successive exclusion zones imposed.
"The exclusion zone has now been lifted and the airport will be open as normal on Tuesday," he said in a midnight statement.
"To everyone who has been affected -- whether you were due to fly on Monday, were evacuated from your home or had your commute to work disrupted by the DLR (Docklands Light Railway) closure -- thank you for your patience and understanding," Sinclair added.
Yesterday's shutdown affected up to 16,000 passengers who were due to fly from London's fifth-biggest airport, although some airlines switched their flights to the city's other hubs.
The bomb disposal operation initially saw the evacuation of up to 500 residents, who were allowed to return to their homes on Monday evening while others were evacuated from another area after the 1.5-metre shell was moved within the dock.
The Newham Council local authority established a rest centre and asked residents to stay with family or friends if possible.
Removal of the fused device had depended on the tides, which left authorities waiting until around midnight before they could transport the bomb further along the River Thames to be safely dealt with.
Jonny Campbell, the naval officer in charge of the bomb disposal divers, said the ordnance would be towed along the river after being removed from the sea bed.
"We will then attach high-grade military explosives before carrying out a controlled explosion," he added.
London was heavily bombed during the "Blitz", the Nazi German air attacks of September 1940 to May 1941.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)