Macron, during a phone call with Trump, stressed France's determination to see "the strict application of the deal and the importance of all the signatories to respect it," the Elysee Palace said of the 2015 accord.
President Trump, who openly despises the deal, is soon to decide whether or not to renew sanctions against Tehran.
The White House said Trump had "underscored that Iran must stop its destabilising activity in the region."
On Friday, Trump is expected to announce that he continues to regard remaining in the Iran nuclear deal not to be in US interests.
One of the criticisms levelled at the nuclear deal is that it does nothing to address Iran's continuing ballistic missile programme and meddling in Middle East conflicts such as Yemen and Syria.
The French presidency stressed that the nuclear deal must be accompanied by reinforced dialogue with Tehran on both issues.
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