The former West Ham United player was forced off with a hamstring injury in the first half of Marseille's Europa League final defeat against Atletico Madrid on Wednesday, and that fitness doubt persuaded Deschamps to leave him out of the squad of 23.
"Dimitri Payet was a serious candidate for a place in the squad. He played the first half-hour (against Atletico), but he aggravated his injury, and the recovery time needed for that type of injury is three weeks," Deschamps said after revealing his squad live on television station TF1's evening news programme.
"It always seems impossible until it's done", wrote Mendy on Twitter.
"I dreamed of participating in this World Cup like all the children who will watch this World Cup," said the 19-year-old Mbappe.
"But now it's a reality and I will work during training to be the best performer possible to help the team." However, Arsenal's Alexandre Lacazette has to settle for a place as one of 11 players on a standby list, who could be called up in the event of injuries.
Deschamps has until June 4 before submitting his definitive squad list. Another player to miss out was Arsenal defender Laurent Koscielny, who ruptured an Achilles tendon playing against Atletico in the Europa League semi-finals.
Real Madrid striker Karim Benzema's international exile goes on -- he has not played for France since October 2015 after being accused of involvement in a blackmail affair involving a sextape.
"Two years have passed. I have put my faith in players who have responded to that, and the squad comes before everything else," Deschamps said.
France squad: Goalkeepers: Hugo Lloris (Tottenham Hotspur/ENG), Steve Mandanda (Marseille), Alphonse Areola (Paris Saint-Germain) Defenders: Lucas Hernandez (Atletico Madrid/ESP), Presnel Kimpembe (Paris Saint-Germain), Benjamin Mendy (Manchester City/ENG), Benjamin Pavard (Stuttgart/GER), Adil Rami (Marseille), Djibril Sidibe (Monaco), Samuel Umtiti (Barcelona/ESP), Raphael Varane (Real Madrid/ESP) Midfielders: N'Golo Kante (Chelsea/ENG), Blaise Matuidi (Juventus/ITA), Steven N'Zonzi (Sevilla/ESP), Paul Pogba (Manchester United/ENG), Corentin Tolisso (Bayern Munich/GER) Forwards: Ousmane Dembele (Barcelona/ESP), Nabil Fekir (Lyon), Olivier Giroud (Chelsea/ENG), Antoine Griezmann (Atletico Madrid/ESP), Thomas Lemar (Monaco), Kylian Mbappe (Paris Saint-Germain), Florian Thauvin (Marseille).
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)