The 13-man squad for the first in the three-match series at Sabina Park in Kingston is captained by Jason Holder.
Three players missing were Marlon Samuels, Darren Bravo and Leon Johnson who toured the United Arab Emirates last year for three Tests against Pakistan.
For Powell this marks a return to the Test stage for the first time since 2014.
West Indies chairman of selectors Courtney Browne said: "We have a young Test squad, which was admirably led by Jason Holder during the last series and, though there are some noticeable absentees, we believe that the players will give a good account of themselves especially in their own backyard."
West Indies squad: Jason Holder (capt), Devendra Bishoo, Jermaine Blackwood, Kraigg Brathwaite, Roston Chase, Miguel Cummins, Shane Dowrich, Shannon Gabriel, Shimron Hetmyer, Shai Hope, Alzarri Joseph, Kieran Powell, Vishaul Singh.
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