The 30-year-old Czech, ranked 29th in singles, has already skipped the ongoing Wuhan Open.
Following Mattek-Sands' serious knee injury at Wimbledon, Safarova climbed to the doubles number one post, replacing her American partner.
Safarova reached the US Open semi-finals with her compatriot Barbora Strycova earlier in September.
The last tournament she played was Quebec City two weeks ago, where she reached the singles semi-finals as the top seed.
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