There "will be a price to pay" if Syria ever uses chemical weapons again, as the US is ready to take additional action, Pence told reporters travelling with him to Peru to attend the Summit of the Americas.
Calling the strike "successful" and an "extraordinary success", Trump said the strike "degraded and crippled" and "significantly eroded" Syria's ability to use chemical weapons.
"This was the morally right act to take," he said.
Pence said that the Trump administration considered every potential response in developing its plan for the Syrian strike and its monitoring the environment for any retaliation.
There were almost daily calls between France, the UK and the US, he said in response to a question.
At a minimum, Chlorine was used and he said that an investigation could show that Sarin was also used.
Responding to a question, Pence said that the US message to Russia is: "You're on the wrong side of history".
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