ALSO READBritish police hunt culprit in Russian ex-spy's poisoning UK police 'know more' about substance involved in Russia spy mystery UK police believe Russian spy targeted with deadly nerve agent UK govt holds urgent meeting on poisoning of ex-Russian spy UK urges 'cool heads' over spy poisoning as Moscow tensions rise
A policeman also fell ill after coming to their aid but is showing signs of recovery, according to interior minister Amber Rudd.
"The two targets are still in very serious condition, the policeman is talking and is engaging so I'm more optimistic for him, but it's too early to say," she told ITV1's Good Morning Britain.
On Wednesday, British police confirmed for the first time that a nerve agent was used and that their probe was now an attempted murder investigation.
"Police are now in a position to confirm that their symptoms are a result of exposure to a nerve agent," said the Metropolitan Police.
"Scientific tests by government experts have identified the specific nerve agent used which will help identify the source."
The Times newspaper reported on Thursday that Skripal's condition was particularly severe, quoting a senior unnamed British government official.
"The feeling is that he is not going to make it out of this," the source told the newspaper. "I think it could be more positive (for Yulia)."
Police have cordoned off an Italian restaurant and a pub that the pair are believed to have visited.
A diner in the restaurant told the Times that Skripal had eaten there on Sunday, and that he was in an agitated state.
"He was going absolutely crazy, I didn't understand it and couldn't understand them," the witness said.
"He didn't seem ill physically but perhaps mentally ill with the way he was shouting."
Police say they are keeping an open mind about what happened, but Foreign Secretary Boris Johnson has alluded to Russia.
He noted the "echoes" with the 2006 poisoning in London of former Russian spy and Kremlin critic Alexander Litvinenko, which Britain has blamed on Russia.
Defence Secretary Gavin Williamson told British television on Thursday that Russia was "becoming an ever-greater threat". Fellow Conservative MP Nick Boles tweeted that "I do not see how we can maintain diplomatic relations with a country that tries to murder people on British soil."
However, the interior minister called for "cool heads" while the police investigated.
Moscow accused British politicians and journalists of whipping up anti-Russian sentiment, with Kremlin foreign ministry spokeswoman Maria Zakharova telling reporters the story "was straight away used to boost an anti-Russian campaign in the media".
Hundreds of counter-terrorism detectives are working "around the clock" to create a timeline of the victims' movements, with "many hours" of CCTV under review, police said.
The Times reported police are probing whether Skripal's daughter, who arrived in Britain from Moscow last week with "gifts from friends", may have inadvertently brought the nerve agent into the country.
The paper previously said investigators would also examine the 2012 death of Skripal's wife from cancer, and that of his 44-year-old son last year in St Petersburg, reportedly from liver problems.
Skripal was a former colonel in Russian military intelligence who was jailed in his country for betraying agents to Britain's MI6 secret service.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)