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By Jacob Gronholt-Pedersen and Robert-Jan Bartunek
COPENHAGEN/BRUSSELS (Reuters) - Denmark's Novo Nordisk, the world's biggest insulin maker, went public with a 2.6 billion euro ($3.1 billion) bid for Belgian biotech group Ablynx on Monday, seeking a new source of growth by bolstering its treatments for rare blood disorders.
Ablynx rejected Novo's latest takeover approach and analysts predict the Danish group, whose new chief executive is trying to expand by buying drugs developed by competitors, might face counterbidders and would need to raise its bid.
Shares in Ablynx closed up 45 percent at 30.80 euros, above the 30.50 euros per share Novo has offered. The bid represents a 60 percent premium to the Belgian company's share price on Dec. 6, which was before Novo's first approach.
The unsolicited bid comes at a time of renewed interest by large drugmakers in smaller biotech firms, with U. S.-based Celgene clinching a deal to buy Impact Biomedicines for up to $7 billion on Sunday and Japan's Takeda Pharmaceutical agreeing last week to buy another Belgian biotech group TiGenix for $630 million.
It later said that Peter Fellner, its chairman since 2013, had decided to resign with immediate effect.
It did not say why.
The Belgian group specialises in the research of novel drugs based on nano-bodies found in the immune systems of llamas and alpacas, for which it partners with several of the world's largest pharmaceutical companies.
The main attraction for Novo is Ablynx's experimental drug caplacizumab for the rare bleeding disorder acquired thrombotic thrombocytopenic purpura, which would complement Novo's line-up of blood products focused on haemophilia.
"We have solid growth in our diabetes and obesity business but we are struggling a little bit to maintain the same level of growth momentum in biopharma," Novo's Chief Financial Officer Jesper Brandgaard said.
The Danish company said it would pay 28.00 euros per share in cash for Ablynx and an additional 2.50 euros in a so-called contingent value right (CVR) if certain conditions related to other drugs in Ablynx's research portfolio were met.
Under previous chief executive Lars Rebien Sorensen, Novo sat out a spate of deal-making across the drugs industry and instead focused on its market-leading position making insulin and other diabetes treatments.
Finance chief Brandgaard said the current bid could be revised if Ablynx agreed to engage in talks.
"I think it would be natural to update the bid following a detailed discussion with the board of directors of Ablynx," he said on a conference call, adding that it would be premature to speculate on any increase.
Brandgaard also played down the threat of an interloper, saying: "In terms of counter proposals it is not our understanding that any other bidder is pursuing the target."
BELGIUM'S THRIVING BIOTECH SCENE
"We envisage Novo needing to hike the offer and could see counterbids," the analysts said.
Ablynx's shares have almost doubled in price in the past 12 months, buoyed by successful clinical trial data.
($1 = 0.8353 euros)
(Additional reporting by Stine Jacobsen in Copenhagen, Philip Blenkinsop in Brussels, Ben Hirschler in London and Abinaya Vijayaraghavan in Bengaluru; Editing by Keith Weir/David Evans/Alexander Smith)
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