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Lilly's breast cancer drug combination succeeds key study

Reuters 

By Natalie Grover

(Reuters) - Eli and Co's combination of its experimental breast drug and another widely used treatment slowed disease progression in patients who relapsed or did not benefit enough when treated with the anti-estrogen therapy.

In August, an independent data monitoring committee recommended the late-stage continue without modification, even though interim evaluation suggested the combination treatment was not delaying progression.

Lilly's drug, abemaciclib, is part of the same new class of breast treatments as Pfizer Inc's Ibrance, and Novartis AG's newly approved Kisqali.

The study, named Monarch-2, compared combined use of abemaciclib and anti-estrogen therapy fulvestrant with fulvestrant alone.

said on Monday that data showed the addition of abemaciclib, which is also being evaluated for lung cancer, resulted in a statistically significant improvement in progression-free survival.

The U.S. drugmaker is also evaluating the drug as a single agent in breast patients who have not derived enough benefit from prior treatments, and multiple other studies are testing abemaciclib in combination with other drugs.

said it planned to submit an application to market abemaciclib as a monotherapy in the second quarter, and as a combination therapy in the third quarter.

If approved, abemaciclib will be the third entrant to the U.S. market, more than two years after Ibrance, and just over six months behind Kisqali.

With Monarch-2 supportive of the drug's effectiveness and/or assuring on its long-term safety profile, the odds of monotherapy approval have improved, Bernstein's Timothy Anderson wrote in a client note.

said it would provide detailed data from the at a future medical conference, which analysts predict is likely at the American Society of Clinical Oncology (ASCO) meeting in June.

Abemaciclib could steal a march over its rivals, should data show a higher relative response rate and longer duration of response, as well as good tolerability despite the frequent diarrhea, Anderson added.

Bernstein's forecast of abemaciclib sales of $1.3 billion in 2021 assumes it would enter the market third with no real differentiation, he said, noting if detailed data showed the drug is more competitive, estimates would rise substantially.

After skin cancer, breast is the most common in women in the United States, according to the U.S. Centers for Disease Control and Prevention.

About 40,610 women will die from breast in 2017, the American Society estimates.

Lilly's shares were little changed at $84.68 in morning trading.

(Reporting by Natalie Grover in Bengaluru; Editing by Sai Sachin Ravikumar and Martina D'Couto)

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

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Lilly's breast cancer drug combination succeeds key study

(Reuters) - Eli Lilly and Co's combination of its experimental breast cancer drug and another widely used treatment slowed disease progression in patients who relapsed or did not benefit enough when treated with the anti-estrogen therapy.

By Natalie Grover

(Reuters) - Eli and Co's combination of its experimental breast drug and another widely used treatment slowed disease progression in patients who relapsed or did not benefit enough when treated with the anti-estrogen therapy.

In August, an independent data monitoring committee recommended the late-stage continue without modification, even though interim evaluation suggested the combination treatment was not delaying progression.

Lilly's drug, abemaciclib, is part of the same new class of breast treatments as Pfizer Inc's Ibrance, and Novartis AG's newly approved Kisqali.

The study, named Monarch-2, compared combined use of abemaciclib and anti-estrogen therapy fulvestrant with fulvestrant alone.

said on Monday that data showed the addition of abemaciclib, which is also being evaluated for lung cancer, resulted in a statistically significant improvement in progression-free survival.

The U.S. drugmaker is also evaluating the drug as a single agent in breast patients who have not derived enough benefit from prior treatments, and multiple other studies are testing abemaciclib in combination with other drugs.

said it planned to submit an application to market abemaciclib as a monotherapy in the second quarter, and as a combination therapy in the third quarter.

If approved, abemaciclib will be the third entrant to the U.S. market, more than two years after Ibrance, and just over six months behind Kisqali.

With Monarch-2 supportive of the drug's effectiveness and/or assuring on its long-term safety profile, the odds of monotherapy approval have improved, Bernstein's Timothy Anderson wrote in a client note.

said it would provide detailed data from the at a future medical conference, which analysts predict is likely at the American Society of Clinical Oncology (ASCO) meeting in June.

Abemaciclib could steal a march over its rivals, should data show a higher relative response rate and longer duration of response, as well as good tolerability despite the frequent diarrhea, Anderson added.

Bernstein's forecast of abemaciclib sales of $1.3 billion in 2021 assumes it would enter the market third with no real differentiation, he said, noting if detailed data showed the drug is more competitive, estimates would rise substantially.

After skin cancer, breast is the most common in women in the United States, according to the U.S. Centers for Disease Control and Prevention.

About 40,610 women will die from breast in 2017, the American Society estimates.

Lilly's shares were little changed at $84.68 in morning trading.

(Reporting by Natalie Grover in Bengaluru; Editing by Sai Sachin Ravikumar and Martina D'Couto)

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

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Business Standard
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Lilly's breast cancer drug combination succeeds key study

By Natalie Grover

(Reuters) - Eli and Co's combination of its experimental breast drug and another widely used treatment slowed disease progression in patients who relapsed or did not benefit enough when treated with the anti-estrogen therapy.

In August, an independent data monitoring committee recommended the late-stage continue without modification, even though interim evaluation suggested the combination treatment was not delaying progression.

Lilly's drug, abemaciclib, is part of the same new class of breast treatments as Pfizer Inc's Ibrance, and Novartis AG's newly approved Kisqali.

The study, named Monarch-2, compared combined use of abemaciclib and anti-estrogen therapy fulvestrant with fulvestrant alone.

said on Monday that data showed the addition of abemaciclib, which is also being evaluated for lung cancer, resulted in a statistically significant improvement in progression-free survival.

The U.S. drugmaker is also evaluating the drug as a single agent in breast patients who have not derived enough benefit from prior treatments, and multiple other studies are testing abemaciclib in combination with other drugs.

said it planned to submit an application to market abemaciclib as a monotherapy in the second quarter, and as a combination therapy in the third quarter.

If approved, abemaciclib will be the third entrant to the U.S. market, more than two years after Ibrance, and just over six months behind Kisqali.

With Monarch-2 supportive of the drug's effectiveness and/or assuring on its long-term safety profile, the odds of monotherapy approval have improved, Bernstein's Timothy Anderson wrote in a client note.

said it would provide detailed data from the at a future medical conference, which analysts predict is likely at the American Society of Clinical Oncology (ASCO) meeting in June.

Abemaciclib could steal a march over its rivals, should data show a higher relative response rate and longer duration of response, as well as good tolerability despite the frequent diarrhea, Anderson added.

Bernstein's forecast of abemaciclib sales of $1.3 billion in 2021 assumes it would enter the market third with no real differentiation, he said, noting if detailed data showed the drug is more competitive, estimates would rise substantially.

After skin cancer, breast is the most common in women in the United States, according to the U.S. Centers for Disease Control and Prevention.

About 40,610 women will die from breast in 2017, the American Society estimates.

Lilly's shares were little changed at $84.68 in morning trading.

(Reporting by Natalie Grover in Bengaluru; Editing by Sai Sachin Ravikumar and Martina D'Couto)

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

image
Business Standard
177 22