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Biocon Ltd has announced that CANMAb (150 mg/440 mg), a biosimilar trastuzumab for the treatment of HER2-positive metastatic breast cancer, will be available to patients around the first week of February 2014. CANMAb, developed jointly by Biocon and Mylan under a global partnership, is the world’s first biosimilar version of Herceptin.
CANMAb is being manufactured at Biocon’s biologics facility in Bangalore and will be available at about 25% discount to the current list price of the reference product in India, which is already significantly lower than its price in developed markets. In addition, CANMAb 150 mg formulation, priced at Rs 19,500/vial, will allow extra savings to patients as they can buy smaller quantities as per their requirement.
According to the company, breast cancer is the most prevalent cancer among Indian women ahead of cervical cancer and CANMAb will offer a high quality, more affordable option to breast cancer patients in India. Approximately, 1.5 lakh new patients are diagnosed with breast cancer every year in India, of which nearly 25% cases are HER2-positive and eligible for treatment with CANMAb.
Kiran Mazumdar-Shaw, Chairperson & Managing Director, Biocon Ltd, said, “Biocon intends to make a significant difference in the treatment paradigm for HER2-positive breast cancer in India by enhancing access to more affordable treatment with CANMAb (biosimilar trastuzumab), which offers the same level of safety and efficacy as the reference product.”
CANMAb is a targeted therapy for the treatment of HER2-positive breast cancer and acts by interfering with HER2 protein production and stopping the growth of cancer cells. It is easy to administer and will be given intravenously, once every 3 weeks or on a weekly basis depending on the patient’s condition. Unlike the product currently available in the market, both 150 and 440 mg formulations of CANMAb can be stored for 1 month which is an important offering for patients in India, as it will ensure that there is no under dosing or wastage of drug which is quite common today.
“India is witnessing increased usage of targeted therapies like biologics as compared to
cytotoxics. This trend is likely to continue given the improved treatment outcomes. The relatively higher cost of developing biologics means these drugs remain unaffordable for a large section of the population. The introduction of high quality biosimilars like CANMAb will make access more affordable and thereby expand the patient pool,” said the company in a press release.
The global sales for Herceptin stood at about $ 6.4 billion in 2012, while in India it recorded sales of $ 21 million.