It had posted a net profit of Rs 1,559.9 crore for the corresponding period last year.
The bank's net interest income was up 15.3% to Rs 4,476.5 crore from Rs 3,731.7 crore in the second quarter of the previous fiscal.
The non-interest income increased by 25.3% to Rs 1,471.8 crore, HDFC Bank said in a statement.
The net interest margin of the bank declined marginally to 4.3% as against 4.4%.
The bank's total income moved up to Rs 11,937.7 crore for the quarter, from Rs 10,146.7 crore in the corresponding period last year, it said.
The second largest private sector lender saw its balance sheet size increase 14.2% to Rs 4,31,166.77 crore at the end of the reporting quarter.
Its net advances were up 16% at Rs 2,68,617 crore as compared to the September 2012 figure, while deposits were up 14.2% at Rs 3,13,011 crore.
The bank scrip was trading at Rs 657.50, down 1.45%, in the afternoon trade on the BSE.
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