Police initially estimated that between five and 15 people had perished in the blast, which rocked the town of West, located about 30 km north of Waco and 128 km south of Dallas, shortly before 8 pm local time on Wednesday. Ground motion from the blast registered as a magnitude 2.1 seismic tremor and created a jolt felt 80 miles away in Dallas, the US Geological Survey reported.
Rescue teams searched the charred rubble of homes on Thursday for survivors as the explosion destroyed dozens of buildings. Three to four volunteer firefighters were among the missing following the blast, said Sgt William Patrick Swanton of the Waco, Texas, police department.
Firefighters had been fighting a fire at the West Fertilizer Co for about 20 minutes before the blast rocked West, a town of 2,700 people.
The plant had tanks of volatile anhydrous ammonia, including what initial reports said was a tanker-sized container like those hauled on freight trains, Swanton said at a news conference on Thursday. However, the immediate threat from fumes appeared to have abated, he said.
The blast destroyed 60 to 80 houses, officials said. It reduced a 50-unit apartment complex to what one local official called "a skeleton standing up" and left a horrific landscape of burned-out buildings and blackened rubble.
"It looks like a war zone with all the debris," McLennan County Sheriff Parnell McNamara said.
Amid such devastation, the death toll remained a rough estimate of five to 15 people, Swanton said. He said more than 160 people were injured and that number was likely to rise.
Emergency crews were moving from house to house in a search and rescue operation, Stanton said.
"That's good news to me, meaning that they're probably still getting injured people," he said. "They have not gotten to the point of no return where they don't think that there's anybody still alive."
Firefighters missing
The firefighters had been battling the fire and evacuating nearby houses and a nursing home out of concern about possible dangerous fumes before the explosion occurred, Swanton said.
Texas Public Safety Department spokesman D L Wilson said half the town, eight to 10 blocks, had been evacuated. Officials said 133 people were removed from the nursing home.
"There are still firefighters missing," Swanton said. "They were actively fighting the fire at the time the explosion occurred."
The firefighters were members of a large volunteer corps who had arrived on the scene.
One law enforcement official who also served as a firefighter was found alive but in critical condition in a local hospital, Swanton said.
The cause of the fire remained unknown and it was being treated as a crime scene, which was standard procedure, Swanton said.
US President Barack Obama, who flew to Boston for a memorial service for victims of the Boston Marathon bombing, offered support and prayers to the victims in Texas.
The explosion came two days before the 20th anniversary of a fire in Waco that engulfed a compound inhabited by David Koresh and his followers in the Branch Davidian sect, ending a siege by federal agents. About 82 members of the sect and four federal agents died at Waco.
In West, witness Kevin Smith told CBS News he had just climbed the stairs to the second floor of his home when he felt the blast.
"The house exploded. It was just a bright flash and a roar, I thought it was lightning striking the house," Smith said. "I felt myself flying through the air about 10 feet, and it took a second or two to realise that the roof had caved in on me so I knew it wasn't lightning."
Three hospitals in Waco and Dallas reported treating more than 160 injuries from the blast.
The federal Bureau of Alcohol, Tobacco, Firearms and Explosives was one of several agencies investigating.
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