Roughly 530,000 people have died from Covid-19 in the United States, and about 10% of Americans have been fully vaccinated.
Biden said on Wednesday he would use his 8 p.m. EST (0100 GMT) address to discuss "what we've been through as a nation this past year" and lay out the next phase of the government's Covid-19 response.
The president is expected to warn Americans who, like people worldwide, are weary of pandemic restrictions, not to revert to normal behavior prematurely. Biden has urged continued mask wearing, social distancing and good hygiene, and he has discouraged cities and states from loosening their guidelines on large gatherings even as more localities relax restrictions.