How much coffee is too much?

Drinking six or more cups of coffee a day can be harmful and increase the risk of heart ailment by up to 22 per cent, a recent study revealed.

The study was published in the American Journal of Clinical Nutrition.

In Australia, one in six people is affected by cardiovascular disease. It is a major cause of death with one person dying from the disease every 12 minutes.

According to the World Health Organization, cardiovascular disease is the leading cause of death, yet one of the most preventable.

Investigating the association of long-term coffee consumption and cardiovascular disease, researchers Dr Ang Zhou and Elina Hypponen of the Australian Centre for Precision Health said that their research confirms the point at which excess caffeine can cause high blood pressure, a precursor to heart disease.

This is the first time an upper limit has been placed on safe coffee consumption and cardiovascular health.

"Coffee is the most commonly consumed stimulant in the world - it wakes us up, boosts our energy and helps us focus - but people are always asking 'How much caffeine is too much?'," Hypponen said.

"Most people would agree that if you drink a lot of coffee, you might feel jittery, irritable or perhaps even nauseous - that's because the caffeine helps your body work faster and harder, but it is also likely to suggest that you may have reached your limit for the time being," Hypponen added.

"We also know that risk of cardiovascular disease increases with high blood pressure, a known consequence of excess caffeine consumption," Hypponen said.

"In order to maintain a healthy heart and a healthy blood pressure, people must limit their coffees to fewer than six cups a day - based on our data six was the tipping point where caffeine started to negatively affect cardiovascular risk," Hypponen pointed.

Using UK Biobank data of 347,077 participants aged 37-73 years, the study explored the ability of the caffeine-metabolising gene (CYP1A2) to better process caffeine, identifying increased risks of cardiovascular disease in line with coffee consumption and genetic variations.

Hypponen said that despite carriers of the fast-processing gene variation being four times quicker at metabolising caffeine, the research does not support the belief that these people could safely consume more caffeine, more frequently, without detrimental health effects.

"Knowing the limits of what's good for you and what's not is imperative. As with many things, it's all about moderation; overindulge and your health will pay for it," Hypponen said.