The first bomb exploded in the city's posh super market near a medical store, police said.
The bomb was hidden in a plastic bag and exploded when a security guard kicked it for checking, a police official said.
"Both legs of the security guard were blown off and he later died due to excessive bleeding," he said, adding one person was injured in the blast.
Shortly afterwards, the second explosion occurred in Karachi Company area of Islamabad.
The bomb was hidden in a vehicle parked outside another market. The explosion damaged the vehicle but no one was hurt.
No one immediately claimed responsibility for the blasts, but authorities have blamed the Pakistani Taliban for similar attacks across the country.
The blasts came a day after Interior Minister Nisar Ali Khan said that new security policy had been prepared for the safety of big cities and the army will also be part of patrols to check rebel attacks.
The Pakistani warplanes recently pounded militant hideouts in the North Waziristan tribal area bordering Afghanistan, killing at least 75.
The latest attacks were the first to strike the capital since an explosion tore through a bustling fruit and vegetable market in April, killing at least 23 people and injuring over 100.
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