They said a bomber wearing an explosives vest blew himself up at the entrance to General Shalal Shaea's house in the Tawahi district of the port city.
Eight civilians and two guards were killed, while the police chief was not hurt, the sources said.
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It was not immediately clear who was behind the bombing.
The Islamic State jihadist group and Al-Qaeda in the Arabian Peninsula, or AQAP, have established a strong presence in Aden.
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