The accident occurred on the busy Indus Highway in Bhan Saeedabad of Dadu district in the province. The bus was going from Shahdadkot to provincial capital Karachi, they said.
A local police official said that they are investigating the cause of the accident. Radio Pakistan said the dead included several women and children.
Road accident are common in Pakistan. At least 15 people, including a woman and two children, were killed on Saturday when a moving train crushed a packed motorcycle rickshaw at a railway crossing in Sheikhupura of Punjab province.
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