The bus was carrying 60 passengers from a Jakarta church back to the capital after a visit to a hill resort when the accident happened in Cisarua, West Java province, local police spokesman Martinus Sitompul told AFP.
It collided with a pick-up truck then crashed into a food stall before falling up to eight metres (26 feet) into the river.
"Sixteen people died, 32 people were seriously injured, and 10 others were lightly injured," he said.
Fatal accidents are common on Indonesia's poorly maintained roads, especially on densely populated Java island.
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