Ten militants were killed in a US drone strike early today in a northwest tribal district which followed another strike in Dargah Mandi area of North Waziristan in which 6 militants perished, Dawn News reported.
The second strike took place hours after first drone strike killed at least six at the same location.
In the first strike, four missiles were fired at a vehicle parked near a mud compound in Dargah Mandi area of North Waziristan, a security official said.
The last drone attack occurred in Pakistan in the last week of December, 2013, killing three insurgents.
The drone strikes had been temporarily halted since then to provide the Pakistani government a chance to have talks with the Tehrik-e-Taliban Pakistan (TTP) aimed at ending their seven-year insurgency.
However, US President Barack Obama last month made it clear that he will continue to authorise CIA-operated drone strikes and covert operations abroad to capture terrorists based on "actionable intelligence".
Pakistan has criticised drone strikes as a violation of sovereignty and counter-productive to anti-terror efforts.
Ten Uzbek militants entered the Jinnah International Airport on Sunday night from different directions in two groups, resulting in a bloody standoff lasting for about 13 hours that left 37 people dead including 10 terrorists.
A day after the attempted airport siege, Taliban militants attacked a training camp of the Airport Security Force outside Karachi international airport, but fled after Pakistani forces repulsed the assault.
Pressure has been mounting on Pakistan to react after the deadly Karachi airport attack.
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