The incident took place outside a restaurant in the Hub industrial area which links Karachi with the troubled Balochistan province, police said.
President's son Salman Mamnoon, who was apparently the target of the attack, escaped unhurt.
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Superintendent Police Investigation, Hub, Jam Mandokhel said Salman's convoy and district police officer Lasbela Bashir Brohi were passing by the area when the huge explosion occurred.
"An ASI of the Karachi police and three other policemen in Salman's convoy sustained injuries," he said.
According to television channels, the blast was so loud it was heard in nearby areas and glass windows of nearby shops were shattered as panic spread among local residents.
No immediately claimed of responsibility for the attack.
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