The bus, travelling from Rawalpindi towards Skardu in Gilgit-Baltistan region, met with the accident in Mansehra district, Dawn reported.
Five persons including two army soldiers and a child were killed and 30 others critically injured in the accident, officials said.
Eyewitnesses said the accident was caused due to over-speeding. The injured passengers have been shifted to the nearby hospital.
Six soldiers were reportedly injured in the accident. The soldiers were travelling to Skardu to report for duty.