"The IED (Improvised Explosive Device) blast took place on Miranshah-Ghulamkhan road this morning," the Pakistani military's media wing, ISPR, said.
It said eight personnel have been killed in the blast.
North Waziristan is a safe haven for the Pakistani Taliban militants and other terror groups including the al-Qaeda.
The attack comes amidst efforts by the government to find a solution to the indiscriminate violence through talks with the Taliban.
This is the first major attack on Pakistani military in the recent past.