The Britain-based Syrian Observatory for Human Rights said the air raids - seven strikes in total - hit the northeastern city of Raqqa early afternoon. Four women were among the dead and dozens of people were wounded, the Observatory said.
Rebels captured Raqqa, the capital of the province of the same name, in March. It's the only major urban center to fall entirely under opposition control since the Syrian conflict began in March 2011.
Rebels also control territory in the north and parts of Aleppo, Syria's largest city and its commercial center.
Last week, at least 50 people were reported killed in two helicopter attacks on a rebel-held town near Aleppo.
Activists say air-strikes often precede government ground offensives. Assad's troops may be mounting a major operation to recapture territory and bolster its position ahead of peace talks planned for January in Geneva.
Assad's control of Syria's skies is hampering rebels' efforts to hold on to territory they capture and administer it with any efficiency.
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